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For individuals experiencing mild gastrointestinal upset from B12 supplements (uncommon but possible with high doses), taking the supplement with breakfast may improve tolerance
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Authors reported small statistically significant differences in weekly weight loss at the 1 mg dose with a non-linear dose response, but the abstract data has not been published in full peer-reviewed form
Concomitant use of metformin and proton pump inhibitors and vitamin B12 deficiency
Consulting with a healthcare provider before extended travel can help optimize dosing strategies and ensure adequate medication supply for the entire trip duration plus a few extra days in case of travel delays
